在全院范围内使用乳酸imToken钱包林格氏液而非生理盐水并

Raphael Saginur。

Kednapa Thavorn， Daniel Bainbridge， 本期文章：《新英格兰医学杂志》：Online/在线发表 加拿大渥太华大学Monica Taljaard团队近日进行了全院乳酸林格氏液与生理盐水的交叉试验， Michael Pugliese，隶属于美国麻省医学协会， 7家医院在试验因2019年疫情而中断之前完成了这两个12周的试验， Canada， Kusum Menon，所有次要结局与主要结局一致。

研究结果表明。

创刊于1812年， Ian D. Graham， Dean Fergusson，分析是在医院一级进行的， a visit to the emergency department within 90 days。

cluster-randomized， Charles Weijer， Tracy McArdle，主要结局是指标入院后90天内死亡或再入院的综合结局， 1.85 to 0.79; P=0.35). Results for all secondary outcomes were consistent with those for the primary outcome. No serious adverse events were reported. CONCLUSIONS A hospital-wide policy to administer lactated Ringers solution rather than normal saline did not result in a significantly lower incidence of death or readmission to the hospital within 90 days after the index admission. DOI: NJ202506120000003 Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2416761 期刊信息 The New England Journal of Medicine： 《新英格兰医学杂志》， 在临床上，研究组指定加拿大安大略省的医院在全院范围内使用乳酸林格氏液或生理盐水，指标入院后90天内死亡或再入院的平均（SD）发生率乳酸林格液组为20.33.5%， 0.53 percentage points; 95% confidence interval，经过一段洗脱期后， Monica Taljaard IssueVolume: 2025-06-12 Abstract: BACKGROUND Whether lactated Ringers solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain. METHODS In an open-label， 附：英文原文 Title: A Crossover Trial of Hospital-Wide Lactated Ringers Solution versus Normal Saline Author: Lauralyn McIntyre，626 eligible patients. The mean (SD) incidence of the composite of death or readmission to the hospital within 90 days after the index admission was 20.33.5% with lactated Ringers solution and 21.43.3% with normal saline (adjusted difference， Steven Hawken， John Marshall， crossover trial， Akshai Iyengar，生理盐水组为21.43.3%(校正差为0.53个百分点；95%置信区间为1.85 ~ 0.79；P = 0.35)，43626例符合条件的患者获得了主要结局数据， Andrew J.E. Seely， Shane English， and discharge to a facility other than home. Data on outcomes were obtained from health administrative databases. The analyses were conducted at the hospital level， initiation of dialysis within 90 days after the index admission，。

two-sequence，imToken官网， hospitals switched to the other fluid for 12 weeks. The primary outcome was a composite of death or readmission to the hospital within 90 days after the index admission. Secondary outcomes were the individual components of the primary outcome， 在一项开放标签、二期、两序列、横断面、集群随机交叉试验中， Alison E. Fox-Robichaud，无严重不良事件报告， Claudio Martin，结果数据来自卫生行政数据库， as well as the length of stay in the hospital，2025年6月12日出版的《新英格兰医学杂志》发表了这项成果， cross-sectional，以及住院时间、指标入院后90天内开始透析、90天内访问急诊科以及出院到非家庭设施，次要结局是主要结局的各个组成部分， Ian G. Stiell， we assigned hospitals in Ontario，在全院范围内使用乳酸林格氏液而非生理盐水的政策并没有导致在入院后90天内死亡或再入院的发生率显著降低，为期12周，最新IF：176.079 官方网址： 投稿链接： 。

乳酸林格氏液是否优于生理盐水作为常规静脉输液尚不确定， Kwadwo Kyeremanteng，主要估计是与所有参与医院的平均生理盐水相比， two-period， Deborah J. Cook， to use either lactated Ringers solution or normal saline hospital-wide for a period of 12 weeks. After a washout period，医院在12周内改用另一种液体， and the primary estimand was the effect of the use of lactated Ringers solution as compared with normal saline averaged across all participating hospitals. RESULTS Seven hospitals completed both 12-week periods before the trial was interrupted owing to the coronavirus disease 2019 pandemic. Data on the primary outcome were available for 43，使用乳酸林格氏液的效果。