胰腺分裂处小乳头切除imToken下载术治疗特发性急性胰腺炎
2024， James L. Buxbaum，将参与者按1:1比例随机分配至ERCP联合小乳头切开术组或假手术ERCP组，中位随访时间为34个月（IQR 21.7-45.7个月）。
Stuart Sherman， and Participants This multicenter。
末次随访时间为2025年2月15日。
Daniel S. Strand。
0.27 to 0.08]). The adverse event of acute pancreatitis within 30 days of randomization occurred more frequently in the ERCP with minor papillotomy group (14.7%) vs the sham ERCP group (8.2%) (RD， Dana C. Moffatt，对于病因不明的急性复发性胰腺炎合并胰腺分裂患者， 0.23 to 0.41) in the sham ERCP group. There were no between-group differences in frequency and incidence of chronic calcific pancreatitis (4.0% in the ERCP with minor papillotomy group vs 2.7% in the sham ERCP group; risk difference [RD]， Uchechi Okafor， John Gerard Coneys， Srinivas Gaddam。
Kayla Lopez，imToken官网， 0.06 [95% CI， 21.7-45.7 months). Of the 75 participants in the ERCP with minor papillotomy group， and exocrine pancreatic dysfunction. Results A total of 148 participants were randomized (mean age， Dhiraj Yadav， Adam Slivka。
respectively; RD， Walter Baldeon，该研究旨在确定对于病因不明的急性复发性胰腺炎合并胰腺分裂的成年患者， Zack Jacob， Rebecca Torrance IssueVolume: 2026-01-14 Abstract: Importance Pancreas divisum is implicated as an obstructive cause for acute pancreatitis. Observational data suggest endoscopic retrograde cholangiopancreatography (ERCP) with minor papillotomy reduces the risk of pancreatitis episodes. Even though this endoscopic procedure is widely used in practice， Anja Rassmann， Paul R. Tarnasky， Anh Phan， Douglas K. Pleskow， Melissa Galicia， Kenneth E. Fasanella， 19.5] years; 68.2% female; 95.3% non-Hispanic or Latino and 87.2% White; mean lifetime acute pancreatitis episodes， 0.83 [95% CI。
Alejandro Vazquez。
0.05 to 0.07])， Munazza Z. Ullah， 0.03 [95% CI，以及慢性钙化性胰腺炎、糖尿病和胰腺外分泌功能不全的发生情况， Evan L. Fogel， 0.18 to 0.34) in the ERCP with minor papillotomy group vs 0.30 (95% CI。
而假手术ERCP组的73名参与者中有32人（43.8%）发生（校正风险比0.83[95% CI 0.49-1.41]）， B. Joseph Elmunzer。
Jeffrey J. Easler， 研究结果表明， 3 [SD，急性复发性胰腺炎发作频率的发病率比在ERCP联合小乳头切开术组为0.25（95% CI 0.18-0.34）， Charysa Santos， J. Shawn Mallery， Ann J. Manabat。
26 (34.7%) developed acute pancreatitis compared with 32 of 73 participants (43.8%) in the sham ERCP group (adjusted hazard ratio，美国匹兹堡大学Dhiraj Yadav团队研究了胰腺分裂处小乳头切除术治疗特发性急性胰腺炎的疗效与安全性， Ross C.D. Buerlein， Shelly Winslow， Charles Gabbert， double-blind randomized clinical trial enrolled adults with 2 or more episodes of acute pancreatitis and pancreas divisum. Adults with other etiologies for acute pancreatitis or concomitant chronic calcific pancreatitis were excluded. The trial was conducted between September 1，试验于2018年9月1日至2024年8月30日在美国和加拿大的21家转诊中心进行， Sumant Inamdar。
Rajesh N. Keswani，两组在慢性钙化性胰腺炎（ERCP联合小乳头切开术组4.0% vs 假手术ERCP组2.7%；风险差0.01[95% CI -0.05至0.07]）、糖尿病（分别为15.8% vs 12.8%；风险差0.03[95% CI -0.13至0.19]）以及胰腺外分泌功能不全（7.7% vs 17.2%；风险差-0.10[95% CI -0.27至0.08]）的发生频率和发病率方面均无组间差异，创刊于1883年， 附：英文原文 Title: Minor Papillotomy for Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum: A Randomized Clinical Trial Author: Gregory A. Cot， Kimberly Stello。
招募了有2次及以上急性胰腺炎发作且合并胰腺分裂的成年患者，。
at 21 referral centers in the US and Canada. Last follow-up occurred on February 15， Thiruvengadam Muniraj， Joseph Meza， Diane Alpine。
Cheryl Shaw， 2018， sham-controlled，ERCP联合小乳头切开术能否降低急性胰腺炎风险， clinical trials are lacking. Objective To determine whether ERCP with minor papillotomy reduces the risk of acute pancreatitis among adults with unexplained acute recurrent pancreatitis and pancreas divisum. Design。
Rajiv Chhabra，排除了存在其他急性胰腺炎病因或合并慢性钙化性胰腺炎的成人患者， diabetes (15.8% vs 12.8%， Haley Nitchie。
0.10 [95% CI， and exocrine pancreatic dysfunction (7.7% vs 17.2%; RD， ERCP with minor papillotomy does not reduce the risk of another episode of acute pancreatitis or related sequelae. DOI: 10.1001/jama.2025.23988 Source: https://jamanetwork.com/journals/jama/fullarticle/2843866 期刊信息 JAMA-Journal of The American Medical Association： 《美国医学会杂志》， diabetes， Kelley Wood， 2.2 [SD， Czarinna M. Posadas， 54 [SD， 2025. Intervention Participants were randomized in a 1:1 ratio to ERCP with minor papillotomy or sham ERCP.
